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2002
- handle: 10670/1.jm4bq7
- Pausova Zdenka, Jomphe Michèle, Houde Louis, Vézina Hélène, Orlov Sergei N., Gossard Francis, Gaudet Daniel, Tremblay Johanne, Kotchen Theodore A., Cowley Allen W., Bouchard Gerard et Hamet Pavel. (2002). A genealogical study of essential hypertension with and without obesity in French Canadians. Obesity Research, 10, (6), p. 463-470.
- doi: 10.1038/oby.2002.64
Ce document est lié à :
https://constellation.uqac.ca/id/eprint/8316/
Ce document est lié à :
https://dx.doi.org/doi:10.1038/oby.2002.64
Ce document est lié à :
doi:10.1038/oby.2002.64
Mots-clés
Histoire Démographie Génétique obesity-associated hypertension kinship in-breeding ion transport body water démographie généalogie obésité canadien-françaisSujets proches
Family Family structure Families--Social aspects Families--Social conditions Family life Structure, Family Family relationships Relationships, FamilyCiter ce document
Zdenka Pausova et al., « A genealogical study of essential hypertension with and without obesity in French Canadians », Constellation - Université du Québec à Chicoutimi, ID : 10.1038/oby.2002.64
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Objectives: To investigate genetic homogeneity in a set of hypertensive families and in subsets chosen for high and low prevalence of obesity; and to compare fasting insulin and lipids, ion transport, and water homeostasis in the obese and lean families. Research methods and procedures: The study was carried out in a relative population isolate of the Saguenay/Lac St. Jean region in Canada. Genetic homogeneity was evaluated with the mean coeffigcients of kinship (phi) and inbreeding (F) computed with ascending genealogies. Serum insulin and lipids were measured after overnight fasting. Total body water was estimated with bioelectrical impedance. Sodium-lithium countertransport and sodium-potassium co-transport were determined in freshly isolated erythrocytes. Results: F and phi were increased in hypertensive families compared with families selected at random. F and phi were further increased within the subsets of obese and lean families. In addition, fasting insulin, total body water, sodium-lithium countertransport, and sodium-potassium co-transport were higher in the obese than in the lean families. The two subsets of families did not differ by fasting lipids. Discussion: In the Saguenay/Lac St. Jean population, the degree of genetic homogeneity was increased in families selected for hypertension, and it was further increased in subsets of hypertensive families with high and low prevalence of obesity. This suggests that hypertension in lean and obese individuals may represent, at least in part, separate genetic entities. Some of the extra genes shared in common within the subsets may contribute to their differences in body weight, insulin sensitivity, ion transport, and water homeostasis.