The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans Authors' names and affiliations
Fiche du document
2017
- handle: 10670/1.jreh8t
- hal: hal-01403839
- doi: 10.1016/j.arr.2016.11.005
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.arr.2016.11.005
Ce document est lié à :
info:eu-repo/grantAgreement//637647/EU/Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity/IDEM
info:eu-repo/semantics/OpenAccess
Sujets proches
Mobility Internal migrationCiter ce document
Jean-Francois Moreau et al., « The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans Authors' names and affiliations », HAL-SHS : histoire, philosophie et sociologie des sciences et des techniques, ID : 10.1016/j.arr.2016.11.005
Métriques
Partage / Export
Résumé
Immunosenescence is thought to result from cellular aging and to reflect exposure to environmental stressors and antigens, including cytomegalovirus (CMV). However, not all of the features of immunosenescence are consistent with this view, and this has led to the emergence of the sister theory of " inflammaging ". The recently discovered diffuse tissue distribution of resident memory T cells (TRM) which don't recirculate, calls these theories into question. These cells account for most T cells residing in barrier epithelia which sit in and travel through the extracellular matrix (ECM). With almost all studies to date carried out on peripheral blood, the age-related changes of the ECM and their consequences for T cell mobility, which is crucial for the function of these cells, have been largely ignored. We propose an update of the theoretical framework of immunosenescence, based on a novel hypothesis: the increasing stiffness and cross-linking of the senescent ECM lead to a progressive immunodeficiency due to an age-related decrease in T cell mobility and eventually the death of these cells. A key element of this mechanism is the mechanical stress to which the cell cytoplasm and nucleus are subjected during passage through the ECM. This hypothesis is based on an " evo-devo " perspective bringing together some major characteristics of aging, to create a single interpretive framework for immunosenescence.