Effects of rat anti-VEGF antibody in a rat model of corneal graft rejection by topical and subconjunctival routes.
Fiche du document
2011
- handle: 10670/1.jyo3yv
- issn: 1090-0535
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/21245949
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1090-0535
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_6A2AB20742781
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
RatCiter ce document
N. Rocher et al., « Effects of rat anti-VEGF antibody in a rat model of corneal graft rejection by topical and subconjunctival routes. », Serveur académique Lausannois, ID : 10670/1.jyo3yv
Métriques
Partage / Export
Résumé
PURPOSE: To compare the effect of a rat anti-VEGF antibody, administered either by topical or subconjunctival (SC) routes, on a rat model of corneal transplant rejection.METHODS: Twenty-four rats underwent corneal transplantation and were randomized into four treatment groups (n=6 in each group). G1 and G2 received six SC injections (0.02 ml 10 µg/ml) of denatured (G1) or active (G2) anti-VEGF from Day 0 to Day 21 every third day. G3 and G4 were instilled three times a day with denatured (G3) or active (G4) anti-VEGF drops (10 µg/ml) from Day 0 to Day 21. Corneal mean clinical scores (MCSs) of edema (E), transparency (T), and neovessels (nv) were recorded at Days 3, 9, 15, and 21. Quantification of neovessels was performed after lectin staining of vessels on flat mounted corneas.RESULTS: Twenty-one days after surgery, MCSs differed significantly between G1 and G2, but not between G3 and G4, and the rejection rate was significantly reduced in rats receiving active antibodies regardless of the route of administration (G2=50%, G4=66.65% versus G1 and G3=100%; p