Restoring T cell homeostasis after allogeneic stem cell transplantation; principal limitations and future challenges
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25 janvier 2023
- handle: 10670/1.k2ncg6
- doi: 10.3389/fimmu.2018.01237
Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License. , https://creativecommons.org/licenses/by/4.0/deed.fr
Mots-clés
Interleukin-7 Dendritic cells Lymphopenia Lymphocytes Stem cell transplantation GVHD IL-7 SDF-1αSujets proches
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Moutuaata Mohamed Moutuou et al., « Restoring T cell homeostasis after allogeneic stem cell transplantation; principal limitations and future challenges », Papyrus : le dépôt institutionnel de l'Université de Montréal, ID : 10.3389/fimmu.2018.01237
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Résumé
For several leukemia patients, allogeneic stem cell transplantation (allogeneic-SCT) is the unique therapeutic modality that could potentially cure their disease. Despite significant progress made in clinical management of allogeneic-SCT, acute graft-versushost disease (aGVHD) and infectious complications remain the second and third cause of death after disease recurrence. Clinical options to restore immunocompetence after allogeneic-SCT are very limited as studies have raised awareness about the safety with regards to graft-versus-host disease (GVHD). Preclinical works are now focusing on strategies to improve thymic functions and to restore the peripheral niche that have been damaged by alloreactive T cells. In this mini review, we will provide a brief overview about the adverse effects of GVHD on the thymus and the peripheral niche and the resulting negative outcome on peripheral T cell homeostasis. Finally, we will discuss the potential relevance of coordinating our studies on thymic rejuvenation and improvement of the peripheral lymphoid niche to achieve optimal T cell regeneration in GVHD patients.