Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen's disease)
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2023
- handle: 10670/1.m6n4a9
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α-human papillomavirus Bowen's disease Human papillomavirus Next-generation sequencing Squamous cell carcinoma in situSujets proches
Papillomaviridae Infectious human wart virus Human wart virus Human papilloma virus Papillomavirus HPV (Virus) Wart virus Papovaviruses Papilloma virusesCiter ce document
Yoo Sang Baek et al., « Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen's disease) », European Journal of Dermatology, ID : 10670/1.m6n4a9
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Background: The detection rate of human papillomavirus (HPV) in Bowen's disease (BD) varies greatly. Objectives: To detect HPV DNA in BD samples using next-generation sequencing (NGS) and compare HPV detection rates between pelvic and non-pelvic BD. Materials and Methods: We evaluated 99 patients with BD in our institution. DNA was extracted from formalin-fixed and paraffin embedded (FFPE) tissue blocks. The presence of HPV DNA material was detected using special kit-based NGS technology. Clinical characteristics and HPV detection rates were then compared between pelvic and non-pelvic BD samples. Results: HPV was detected in 26 (26.3%) BD samples. A total of 10 types of α-HPV was detected: HPV 16, 53, 31, 58, 66, 26, 27, 57, 45, and 72. The most common HPV type was 16 (12.1%). Only two types (27 and 57) were frequently classified as cutaneous type, and the rest were mucosal types. The HPV detection rate was significantly higher in pelvic BD (45.2%) compared to non-pelvic BD (17.6%). Conclusion: The present study suggests that sexually transmitted mucosal α-HPV plays a significant role in the pathogenesis of BD, especially in the pelvic region.