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2018
- handle: 10670/1.mmdpuc
- hal: hal-01745647
- doi: 10.1016/j.smim.2018.02.013
- PUBMED: 29550156
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.smim.2018.02.013
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/29550156
Ce document est lié à :
info:eu-repo/grantAgreement//637647/EU/Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity/IDEM
info:eu-repo/semantics/OpenAccess
Mots-clés
Tissue repair Tissue regeneration Redundancy Robustness Surveillance Plasticity -bio]/Immunology -bio]/Development Biology -bio]/Human health and pathology/Tissues and Organs [q-bio.TO] -bio]/Human health and pathology/Rhumatology and musculoskeletal systemSujets proches
Natural science Sciences Science of scienceCiter ce document
Marie-Elise Truchetet et al., « Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system », HAL-SHS : histoire, philosophie et sociologie des sciences et des techniques, ID : 10.1016/j.smim.2018.02.013
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Résumé
Robustness, understood as the maintenance of specific functionalities of a given system against internal and external perturbations, is pervasive in today's biology. Yet precise applications of this notion to the immune system have been scarce. Here we show that the concept of robustness sheds light on tissue repair, and particularly on the crucial role the immune system plays in this process. We describe the specific mechanisms, including plasticity and redundancy, by which robustness is achieved in the tissue reconstruction system (TRS). In turn, tissue repair offers a very important test case for assessing the usefulness of the concept of robustness, and identifying different varieties of robustness.