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- handle: 10670/1.mrejrk
- hal: hal-03542494
info:eu-repo/semantics/OpenAccess
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Life, Quality of Funds Funding Pattern Model Cancer therapy Cancer treatment Cancer--Therapy Finance, commerce, confiscations, etcCiter ce document
Peter Bayer et al., « A Markovian decision model of adaptive cancer treatment and quality of life », Archive Ouverte d'INRAE, ID : 10670/1.mrejrk
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This paperdevelopsandanalyzesaMarkovchainmodelforthetreatmentofcancer.Cancer therapyismodeledasthepatient'sMarkovDecisionProblem,withtheobjectiveofmaximizing thepatient'sdiscountedexpectedqualityoflifeyears.Patientsmakedecisionson thedurationoftherapybasedontheprogressionofthediseaseaswellastheirownpreferences. Weobtainapowerfulanalyticdecisiontoolthroughwhichpatientsmayselect theirpreferredtreatmentstrategy.Weillustratethetradeospatientsarefacingin anumericalexampleandcalculatethevaluelosttoacohortwhochoosesuboptimalstrategies. Inasecondmodelpatientsmaymakechoicestoincludedrugholidays.Bydelayingtherapy,thepatienttemporarilyforgoesthegainsoftherapyinordertodelayits sideeects.Weobtainananalytictoolthatallowsnumericalapproximationsoftheoptimal timesofdelay.