Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
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2010
- handle: 10670/1.nlr2f1
- 1413-8123
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http://www.redalyc.org/revista.oa
Ciência & Saúde Coletiva
Mots-clés
Salud Repro products Birth defects ductive health Disinfection bySujets proches
Defects, Birth Malformations, Congenital Congenital anomalies Developmental abnormalities Congenital abnormalities Anomalies, Congenital Human abnormalities Deformities Birth defects AbnormalitiesCiter ce document
Mark J. Nieuwenhuijsen et al., « Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses », Ciência & Saúde Coletiva, ID : 10670/1.nlr2f1
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Résumé
"This study aims to review epidemiologic evidence of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies. All epidemiologic studies that evaluated a relationship between an index of DBP exposure and risk of congenital anomalies were analyzed. For all congenital anomalies combined, the meta-analysis gave a statistically sig-nificant excess risk for high versus low exposure to water chlorination or TTHM (17%; 95% CI, 3-34) based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21- 107), but based on only three studies, and there was little evidence of an exposure-response relationship. It was observed no statistically significant relationships in the other meta-analyses and little evidence for publication bias, except for urinary tract defects and cleft lip and palate. Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such association."