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2006
- handle: 10670/1.o96jv4
- 0717-196X
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http://www.redalyc.org/revista.oa
Theoria
Mots-clés
Multidisciplinarias (Ciencias Sociales) NER PON Polymorphisms MN and Comet Assay Occupational exposureSujets proches
Damage, DNA Influence and resultsCiter ce document
Paula Rohr et al., « The ber pathway genes and pon1 polymorphism: influence on dna damage in agriculture-exposed workers », Theoria, ID : 10670/1.o96jv4
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Résumé
"Pesticide exposure represents a potential risk for human health. Farmers from Rio Grande do Sul (the southernmoststate of Brazil) use different kinds of such substances and are therefore constantly exposed to thosechemical compounds. The aim of this study was to evaluate the influence of polymorphisms in PON1 and intwo BER genes (XRCC1 and OGG1 polymorphisms) in cell damage, analyzing a group of pesticide-exposedfarmers. Genotyping of the three polymorphisms was performed by PCR/RFLP. DNA damage was evaluatedby Comet assay (ID) and Micronuclei test (MN) in 107 pesticide-exposed workers and in 73 nonexposedpeople. Statistically significant differences between cases and controls, considering data from ID,MN and genotyping analysis, were tested by the non-parametric Mann-Whitney U test. PON polymorphismsshowed influence in cell damage in the pesticide-exposed group, considering the frequency of MN:homozygotes Gln/Gln presented a higher incidence of MN when compared to Arg/-(p