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2018
- handle: 10670/1.ondhzq
- 0036-3634
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http://www.redalyc.org/revista.oa
Salud Pública de México
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Salud TNF child obesity MicrobiotaSujets proches
Childhood Youngsters Pedology (Child study) Kids (Children)Citer ce document
Yaneth C Orbe-Orihuela et al., « High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children », Salud Pública de México, ID : 10670/1.ondhzq
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"Objective. To investigate the correlation among pro- or anti-inflammatory cytokines and the two main gut microbiota phyla in obese children. Materials and methods. Anthro - pometric data were obtained from 890 children under 14 years old to determine the degree of obesity. Serum cytokine concentration was measured by ELISA. Relative abundance of gut microbiota in feces was evaluated by quantitative Real-Time PCR assays. Results. Anthropometric and bio - chemical parameters were statistically higher in overweight /obese children than in lean ones. Increased TNF- α levels were found in obese children that also have a high relative abundance of Firmicutes. Conclusions. Obese children have a high relative abundance of Firmicutes that correlates with increased levels of TNF- α . This is the first study that shows a relation between Firmicute abundance and TNF- α serum concentration in obese children."