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1 février 2008
- handle: 10670/1.r0n3vq
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Diterpenoids Speciation (Biology) Spur flowers Begonia, Swedish Prostrate coleus Ivy, Swedish Swedish ivy Spurflowers Swedish begonia Coleus, ProstrateCiter ce document
R.L. van Zyl et al., « Antiplasmodial activities of some abietane diterpenes from the leaves of five Plectranthus species », South African Journal of Science, ID : 10670/1.r0n3vq
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Seven known abietane diterpenes were isolated from five Plectranthus species, namely P. hadiensis, P. lucidus, P. ecklonii, P. purpuratus subsp. purpuratus and P. purpuratus subsp. tongaensis. The seven compounds were tested for their antiplasmodial activity and for their ability to inhibit β-haematin formation. Overall, they showed good activity (IC50 values ranging from 3.11 to 14.65 µM), with one compound being 62% as effective as chloroquine in inhibiting β-haematin formation. However, the cytotoxicity profile indicated a low degree of specificity towards the malaria parasite. When combined with quinine, three compounds interacted in an additive manner whereas one interacted synergistically.