Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure
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4 novembre 2020
- handle: 10670/1.raqph1
- doi: 10.1002/hep.28945
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Constantine J. Karvellas et al., « Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure », Papyrus : le dépôt institutionnel de l'Université de Montréal, ID : 10.1002/hep.28945
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Background/Aim Acetaminophen (APAP)-induced Acute Liver Failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Hypothesis: Serum Liver-type Fatty Acid Binding Protein (FABP1) early (day 1) or late (day 3–5) levels are associated with 21-day mortality in the absence of liver transplant. Methods Serum samples from 198 APAP-ALF patients (nested case control study with 99 survivors, 99 non-survivors) were analyzed by ELISA methods and assessed with clinical data from the US Acute Liver Failure Study Group (ALFSG) Registry (1998–2014). Results APAP-ALF survivors had significantly lower serum FABP1 levels early (238.6 vs. 690.8 ng/ml, p