Factors associated with persistence of early-onset atopic dermatitis up to the age of 12 years: a prospective cohort study in China
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2021
- handle: 10670/1.rc2j31
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Zhen Zhang et al., « Factors associated with persistence of early-onset atopic dermatitis up to the age of 12 years: a prospective cohort study in China », European Journal of Dermatology, ID : 10670/1.rc2j31
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BackgroundAtopic dermatitis (AD) can remit as age increases. However, long-term follow-up studies evaluating disease evolution and related factors of persistence of early-onset AD are sparse. ObjectivesThis study aimed to identify factors associated with the persistence of early-onset AD. Materials & MethodsIn this prospective cohort study, 260 patients with onset of AD before age two years old were enrolled. Clinical examination was performed and a questionnaire survey completed at enrolment. In addition, the filaggrin gene ( FLG) of all participants was sequenced to identify mutations within this gene. Patients were followed at age six and 12. ResultsThe remission rate was 50.8% at age six and 70.3% at age 12. Persistent AD was associated with a higher SCORAD index at baseline ( p