Hospitalisations with infections related to antimicrobial-resistant bacteria from the French nationwide hospital discharge database, 2016
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12 mars 2019
- handle: 10670/1.rdo3bt
- pasteur-04313933
- doi: 10.1017/S0950268819000402
- PUBMED: 30869047
- PUBMEDCENTRAL: PMC6518510
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info:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268819000402
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info:eu-repo/semantics/altIdentifier/pmid/30869047
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MESH: Adolescent MESH: Adult MESH: Middle Aged MESH: Young Adult MESH: Aged MESH: Aged, 80 and over MESH: Bacteria MESH: Bacterial Infections MESH: Child MESH: Child, Preschool MESH: Drug Resistance, Bacterial MESH: Female MESH: France MESH: Hospitalization MESH: Hospitals MESH: Humans MESH: Incidence MESH: Infant MESH: Infant, Newborn MESH: Male -bio]/Human health and pathology/Infectious diseases -bio]/Santé publique et épidémiologieCiter ce document
M. Opatowski et al., « Hospitalisations with infections related to antimicrobial-resistant bacteria from the French nationwide hospital discharge database, 2016 », Archive ouverte de Sciences Po (SPIRE), ID : 10.1017/S0950268819000402
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Résumé
Massive use of antibiotics has led to increased bacterial resistance to these drugs, making infections more difficult to treat. Few studies have assessed the overall antimicrobial resistance (AMR) burden, and there is a paucity of comprehensive data to inform health policies. This study aims to assess the overall annual incident number of hospitalised patients with AMR infection in France, using the National Hospital Discharge database. All incident hospitalisations with acute infections in 2016 were extracted. Infections which could be linked with an infecting microorganism were first analysed. Then, an extrapolation of bacterial species and resistance status was performed, according to age class, gender and infection site to estimate the total number of AMR cases. Resistant bacteria caused 139 105 (95% CI 127 920–150 289) infections, resulting in a 12.3% (95% CI 11.3–13.2) resistance rate. ESBL-producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus were the most common resistant bacteria (>50%), causing respectively 49 692 (95% CI 47 223–52 142) and 19 493 (95% CI 15 237–23 747) infections. Although assumptions are needed to provide national estimates, information from PMSI is comprehensive, covering all acute bacterial infections and a wide variety of microorganisms.