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6 décembre 2007
- handle: 10670/1.s1dn7p
- Glazko, Galina; Makarenkov, Vladimir; Liu, Jing et Mushegian, Arcady (2007). « Evolutionary history of bacteriophages with double-stranded DNA genomes ». Biology Direct, 2(1), p. 36.
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http://archipel.uqam.ca/7832/
Ce document est lié à :
http://dx.doi.org/10.1186/1745-6150-2-36
Ce document est lié à :
doi:10.1186/1745-6150-2-36
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bacteriophage Evolutionary historySujets proches
Phages BacteriophageCiter ce document
Galina Glazko et al., « Evolutionary history of bacteriophages with double-stranded DNA genomes », UQAM Archipel : articles scientifiques, ID : 10670/1.s1dn7p
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Résumé
Background: Reconstruction of evolutionary history of bacteriophages is a difficult problem because of fast sequence drift and lack of omnipresent genes in phage genomes. Moreover, losses and recombinational exchanges of genes are so pervasive in phages that the plausibility of phylogenetic inference in phage kingdom has been questioned. Results: We compiled the profiles of presence and absence of 803 orthologous genes in 158 completely sequenced phages with double-stranded DNA genomes and used these gene content vectors to infer the evolutionary history of phages. There were 18 well-supported clades, mostly corresponding to accepted genera, but in some cases appearing to define new taxonomic groups. Conflicts between this phylogeny and trees constructed from sequence alignments of phage proteins were exploited to infer 294 specific acts of intergenome gene transfer. Conclusion: A notoriously reticulate evolutionary history of fast-evolving phages can be reconstructed in considerable detail by quantitative comparative genomics.