Impaired number and function of lymphocytes in patients with common variable immunodeficiency: a consequence of activation-induced cell death
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2015
- handle: 10670/1.t6umxw
- 1677-1028
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ConScientiae Saúde
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Immunologic deficiency Immune deficiency Immunological deficiency Nongranular leucocytes Expressive behaviorCiter ce document
Paolo Ruggero Errante et al., « Impaired number and function of lymphocytes in patients with common variable immunodeficiency: a consequence of activation-induced cell death », ConScientiae Saúde, ID : 10670/1.t6umxw
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"Introduction: Common variable immunodeficiency (CVID) is an immunological disorder characterized by defective antibody production. Objectives: To study lymphocytes number, surface activation molecules, cell markers, lymphoproliferative response, cytokine production, and cell death. Methods: A study was led on thirty four patients with CVID selected from the Division of Clinical Immunology and Allergies of the Faculty of Medicine of São Paulo University (FMUSP), Brazil. Peripheral mononuclear blood cells (PBMC) of CVID patients and healthy individuals were evaluated in regard to the expression of cell surface markers, activation molecules, lymphoproliferative response, cytokine synthesis and apoptosis. Results: CVID patients showed decrease in T and B lymphocyte counts, CD25, CD69, CD40L, and CD70 expression, and low synthesis levels of IL-4 and IL-5. Furthermore, their lymphocytes were more susceptible to apoptosis following activation. Conclusion: The higher susceptibility to apoptosis following activation may also be responsible for the decrease in the expression of activation molecules and CD40L, in cytokine synthesis, and in levels of circulating T and B cells."