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2 septembre 2006
- handle: 10670/1.vda527
- issn: 0036-7672
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Therapy Treatments for diseases Medical treatment Therapy Treatment of diseases Progenitor cells Mother cells Colony-forming units (Cells) Scientific research Science research Science--Research Marrow Medulla ossium Factors Agents, Manufacturers' Manufacturers' representatives People Man Humanity (Human beings) Human race Mankind Homo sapiens Humankind Humans Cultural sociology Culture--Social aspects Sociology of culture Factors Therapy, Cellular Cells--Therapeutic use Cell therapy Bones--Regeneration Bone--Regeneration Bone corpuscles Osseous cells Stromal cells, Marrow Stromal cells, Bone marrow Bone marrow stromal cells Marrow stromal cells MSCs (Mesenchymal stem cells) Primary sources Forerunners Primary sourcesCiter ce document
D.P. Pioletti et al., « Bone tissue engineering using foetal cell therapy. », Serveur académique Lausannois, ID : 10670/1.vda527
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Different cell sources for bone tissue engineering are reviewed. In particular, adult cell source strategies have been based on the implantation of unfractionated fresh bone marrow; purified, culture expanded mesenchymal stem cells, differentiated osteoblasts, or cells that have been modified genetically to express rhBMP. Several limiting factors are mentioned for these strategies such as low number of available cells or possible immunological reaction of the host. Foetal bone cells are presented as an alternative solution and review of actual treatments using these cells is presented. Finally, foetal cells used specifically for bone tissue engineering are characterised and potentially interesting therapeutic options are proposed.