Results of a Randomized Clinical Trial of Speech after Early Neurostimulation in Parkinson's Disease

Serge Pinto; Adelheid Nebel; Jörn Rau; Robert Espesser; Pauline Maillochon; Oliver Niebuhr; Paul Krack; Tatiana Witjas; Alain Ghio; Marie‐charlotte Cuartero; Lars Timmermann; Alfons Schnitzler; Helke Hesekamp; Niklaus Meier; Julia Müllner; Thomas Hälbig; Bettina Möller; Steffen Paschen; Laura Paschen; Jens Volkmann; Michael Barbe; Gereon Fink; Johannes Becker; Paul Reker; Andrea Kühn; Gerd‐helge Schneider; Valérie Fraix; Eric Seigneuret; Andrea Kistner; Olivier Rascol; Christine Brefel-Courbon; Fabienne Ory-Magne; Christian Hartmann; Lars Wojtecki; Anne Fradet; David Maltête; Philippe Damier; Séverine Le Dily; Friederike Sixel-Döring; Petra Benecke; Daniel Weiss; Tobias Wächter; Marcus Pinsker; Jean Régis; Stéphane Thobois; Gustavo Polo; Jean‐luc Houeto; Andreas Hartmann; Karina Knudsen; Marie Vidailhet; Michael Schüpbach; Günther Deuschl

Results of a Randomized Clinical Trial of Speech after Early Neurostimulation in Parkinson's Disease

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2023

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Linguistique

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Anglais

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HAL-SHS : linguistique

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info:eu-repo/semantics/altIdentifier/doi/10.1002/mds.29282

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Centre pour la communication scientifique directe

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-bio]/Neurons and Cognition [q-bio.NC]

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Talking

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Serge Pinto et al., « Results of a Randomized Clinical Trial of Speech after Early Neurostimulation in Parkinson's Disease », HAL-SHS : linguistique, ID : 10.1002/mds.29282

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Background: The EARLYSTIM trial demonstrated for Parkinson ’ s disease patients with early motor complications that deep brain stimulation of the subthalamic nucleus (STN-DBS) and best medical treatment (BMT) was superior to BMT alone.Objective: This prospective, ancillary study on EARLYSTIM compared changes in blinded speech intelligibility assessment between STN-DBS and BMT over 2 years, and secondary outcomes included non-speech oral movements (maximum phonation time [MPT], oral diadochokinesis), physician- and patient-reported assessments.Methods: STN-DBS (n = 102) and BMT (n = 99) groups underwent assessments on/off medication at baseline and 24 months (in four conditions: on/off medication, ON/OFF stimulation — for STN-DBS). Words and sentences were randomly presented to blinded listeners, and speech intelligibility rate was measured. Statistical analyses compared changes between the STN-DBS andBMT groups from baseline to 24 months.Results: Over the 2-year period, changes in speech intelligibility and MPT, as well as patient-reported outcomes, were not different between groups, either off or on medication or OFF or ON stimulation, but most outcomes showed a nonsigniﬁcant trend toward worsening in both groups. Change in oral diadochokinesis was signiﬁcantly different between STN-DBS and BMT groups, on medi-cation and OFF STN-DBS, with patients in the STN-DBS group performing slightly worse than patients under BMT only. A signal for clinical worsening with STN-DBS was found for the individual speech item of the Uniﬁed Parkinson’ s Disease Rating Scale, Part III.Conclusion: At this early stage of the patients ’ disease, STN-DBS did not result in a consistent deterioration in blinded speech intelligibility assessment and patient-reported communication, as observed in studies of advanced Parkinson’ s Disease.

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Results of a Randomized Clinical Trial of Speech after Early Neurostimulation in Parkinson's Disease

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