Frequency of antibodies against the hepatitis C virus in patients with hepatic cirrhosis in Yucatan, Mexico
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2003
- handle: 10670/1.w0l8cp
- 0036-3634
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Salud Pública de México
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HCV (Hepatitis C virus) Immune globulins Antibodies Immune serum globulin Serum hepatitis Homologous serum hepatitisCiter ce document
Renán A Góngora et al., « Frequency of antibodies against the hepatitis C virus in patients with hepatic cirrhosis in Yucatan, Mexico », Salud Pública de México, ID : 10670/1.w0l8cp
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Résumé
"Objective. To report the prevalence of antibodies againstthe hepatitis C virus (anti-HCV) in a group of patients withhepatic cirrhosis (HC). Material and Methods. A prospectivetransversal and descriptive study was carried outfrom March 1998 to May 1999. Study subjects were 153patients; 117 (76%) male and 36 (24%) female, diagnosedwith HC. They were attended at the General Hospital AgustínO Horan and at Regional Research Center DoctorHideyo Noguchi, in Merida, Yucatan, Mexico. A clinical-epidemiologicquestionnaire completed by interview was usedfor data collection. Anti-HCV were detected using a 2ndgeneration enzyme-linked immunosorbent assay (ELISA-2).To confirm diagnosis, a second generation recombining immunoblotassay (RIBA-2) was used. Hepatitis B surface antigen(HbsAg) and antibodies against the hepatitis B coreantigen (anti-HBc) were determined using ELISA. The presenceof anti-HCV was related to the epidemiologic variablesof study subjects. The prevalence of anti-HCV wasobtained and the frequency of the characteristics obtainedby interview were compared among the positive and negativepatients through the c2 test and the Fishers exacttest, as needed. Results. Among patients with HC (35/117(30%) male and 14/36 (39%) female), 32 % were positive toanti-HCV. Alcoholism was present in all seroreactive malesand absent in all positive females (p< 0.001). Data obtainedthrough an interview were not associated with seropositivity. Anti-HBc was found in 16% of patients positive to anti-HCV and in 12% of seronegatives (p=0.69). Conclusions.The prevalence found was greater than previous reports inthe general population in the Yucatan Peninsula (1.3%). Thehigh prevalence of anti-HCV in these patients suggests thatHC is more frequently associated with HCV in Yucatan,Mexico than hepatitis B. Alcoholism probably acts as a cofactorfor the development of HC in males."