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11 juillet 2024
- handle: 10670/1.wiq63u
- eisbn: 978-2-7226-0775-0
info:eu-repo/semantics/openAccess , https://www.openedition.org/12554
Mots-clés
oncology cell biology molecular biology cancer carcinogenesis therapeutics genetics oncogenesis biology Multidisciplinary MED000000Sujets proches
Tumorigenesis Pathogenesis of cancer Cancer--Pathogenesis Oncogenesis Carcinoma Cancers Malignancy (Cancer) Malignant tumorsCiter ce document
Hugues de Thé, « Oncology: From Empiricism to Integrative Biology », Collège de France, ID : 10670/1.wiq63u
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Résumé
After decades of descriptive studies, the biology of cancer is undergoing a real revolution: with genetic approaches, researchers have identified many of the cell deregulations likely to drive tumours. A treatment combining arsenic and retinoic acid targets the protein responsible for promyelocytic leukaemia. This treatment, which has cured virtually all patients, gives hope that the in-depth understanding of carcinogenesis mechanisms may lead to new therapeutic approaches that could be transposed to other cancers.