Huntington's disease affects movement termination

Fiche du document

Date

2008

Type de document
Périmètre
Langue
Identifiants
  • handle:  10670/1.y48ih7
  • Lemay, M.; Chouinard, S.; Richer, François et Lespérence, P. (2008). « Huntington's disease affects movement termination ». Behavioural Brain Research, 187(1), pp. 153-158.
Relations

Ce document est lié à :
http://archipel.uqam.ca/674/

Ce document est lié à :
17980441

Licence


Résumé 0

Huntington's disease (HD) is a neurodegenerative disease affecting the striatum and associated with deficits in voluntary movement in early stages. The final portion of aiming movements is particularly affected in HD and one hypothesis is that this deficit is linked to attention or terminal control requirements. Sixteen patients with early HD and 16 age-matched controls were examined in aiming movements. Four conditions manipulated movement termination requirements (discrete movements with a complete stop vs cyclical back-and-forth movements) and the presence of flankers around the target. Reducing movement termination requirements significantly attenuated deficits in the final movement phase in patients. The presence of flankers around the target affected the initial portion of movements but did not affect the two groups differentially. These results indicate that terminal control requirements affect voluntary movements in HD. This suggests that frontostriatal systems are involved in movement termination.

document thumbnail

Par les mêmes auteurs

Sur les mêmes sujets

Sur les mêmes disciplines

Exporter en