Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer
Fiche du document
30 janvier 2023
- handle: 10670/1.yc1f6m
- doi: 10.3389/fimmu.2013.00006
Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 3.0 non transposé / License Creative Commons Attribution 3.0 Unported , https://creativecommons.org/licenses/by/3.0/
Mots-clés
Graft-vs-host disease Autoimmunity Cancer Graft tolerance Immunoregulation Double negative T cellsSujets proches
Thymus-dependent lymphocytes Thymus-derived cells T lymphocytes Thymus-dependent cellsCiter ce document
Erin Hillhouse et al., « Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer », Papyrus : le dépôt institutionnel de l'Université de Montréal, ID : 10.3389/fimmu.2013.00006
Métriques
Partage / Export
Résumé
A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the treatment of hematological malignancies is the prevention of graft-vs-host disease (GVHD) while maintaining graft-vs-tumor activity. Interestingly, CD4-CD8- (double negative, DN) T cells, which exhibit a unique antigen-specific immunoregulatory potential, appear to exhibit all of the properties to respond to these challenges. Herein, we review the therapeutic potential of immunoregulatory DN T cells in various immunopathological settings, including graft tolerance, GVHD, cancer, and autoimmunity.