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2011
- handle: 10670/1.z1ji2x
- 1677-1028
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http://www.redalyc.org/revista.oa
ConScientiae Saúde
Mots-clés
Salud Atenolol Hypertension PharmacokineticsSujets proches
Physical activity Warm-up Workouts (Exercise)Citer ce document
Naiane Ferraz Bandeira Alves et al., « Autonomic modulation and chronotropic activity during aerobic exercise in patients using atenolol », ConScientiae Saúde, ID : 10670/1.z1ji2x
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Résumé
"Introduction: The negative chronotropic effect of beta-blockers (BB) can modify itself according to its pharmacokinetics. Objective: To investigate the influence of pharmacokinetics of beta-blockers in heart rate (HR) and autonomic activity (AA) in response to the exercise. Methods: Three groups of hypertensive patients, users of atenolol (n=9), enalapril, (n=8), and a normotensive control group (n=8), performed two sessions of moderate exercise on a cycloergometer, during 40 minutes, whereby 2 hours (Session I), or 23 hours after drug administration (Session II). Records of electrocardiogram were made before, during and after the exercises. Results: The HR was lower in session I comparing with session II of the atenolol group during the exercise. There were no differences in the components of low and high frequency of AA between these sessions. Conclusions: These results confirm the negative chronotropic effect of BB. However, the absence of changes in AA suggests that other mechanisms may be contributing to this phenomenon."