In vivo killing of Staphylococcus aureus by toluidine blue-mediated photosensitization in an animal model wounds
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2008
- handle: 10670/1.zics4n
- 1677-1028
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ConScientiae Saúde
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Tolonium chloride Toluidine blue OCiter ce document
Paulo de Tarso Camillo de Carvalho et al., « In vivo killing of Staphylococcus aureus by toluidine blue-mediated photosensitization in an animal model wounds », ConScientiae Saúde, ID : 10670/1.zics4n
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"The aims of this study were to determine whether S. aureus could be killed by toluidine blue-mediated photosensitization in vivo in an animal model. Twelve Wistar rats divided into three groups (n = 12): Group I: Control Group, the wounds were made and submitted to the application of the laser without the drug photosensitizing; Group II: The implementation of wounds received the toluidine blue, without application of laser; Group III: it was used toluidine blue, and application of laser- Indio phosphide Gallium-Aluminum (InGaAIP) ¿ 660nm power and density of 20 Joules/cm2. Statistical analysis of CFU by analysis of variance Kruskal-Wallis test shows significant intraoperative difference, photodynamic therapy group (p < 0, 05), the Dunns post hoc test shows significant difference between Group I when compared to Group II treated with LLLT (p < 0001). The results of this study show that photodynamic therapy with toluidine blue has reduced the number of Staphylococcus aureus in vivo."