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- 20.500.11794/164343
- 1941-9651
- doi: 10.1161/CIRCIMAGING.124.017858
- 40340592
http://purl.org/coar/access_right/c_f1cf
Mots-clés
Aortic valve Ethnicity Hemodynamics Humans Retrospective studies Valve aortique -- Physiopathologie -- Différences entre sexes Aorte -- Rétrécissement Aortographie Valve aortique -- Chirurgie Valve aortique -- Tomographie Études cliniques Hémodynamique EthnicitéSujets proches
Womyn Wimmin Woman Womon Human females Women's workCiter ce document
Daniel Lorenzatti et al., « Characterization of aortic valve stenosis by CT angiography in a diverse US cohort », CorpusUL, l'archive ouverte de l'université Laval, ID : 10.1161/CIRCIMAGING.124.017858
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Background: Aortic stenosis (AS) involves calcific and fibrotic degeneration of the valve tissue. The only noninvasive method for evaluating both processes is contrast-enhanced computed tomography angiography. We aimed to explore the differences in aortic valve (AV) tissue composition across sex, race/ethnicity, and AS hemodynamic phenotype in US patients referred for transcatheter AV replacement planning. Methods: We retrospectively analyzed symptomatic patients with AS who underwent computed tomography angiography for transcatheter AV replacement planning between 2015 and 2022. Using semi-automated software, we quantified the AV tissue composition by fibrotic, calcific, and fibro-calcific volumes, and the fibro-calcific ratio (fibrotic/calcific volume) as a measure of valve phenotype. Results: The study included 651 patients (mean age 84 years; 55% women) with 38% non-Hispanic (NH)-White, 27% Hispanic, and 13% NH-Black. Women had lower fibro-calcific (230 versus 293 mm³/cm²; P
