Common polymorphisms in the promoter of the visfatin gene (PBEF1) influence plasma insulin levels in a French Canadian population
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- 20.500.11794/39706
- 0012-1797
- doi: 10.2337/db06-0189
- 17003359
http://purl.org/coar/access_right/c_16ec
Mots-clés
Nicotinamide phosphoribosyltransferase Nicotinamide Adipokines Insuline Canadiens français Graisse intraabdominale Polymorphisme génétique GènesSujets proches
Vitamin B3 Vitamin PP Nicotinic acid amide Niacinamide Populations, Human Human populations Population growth Human population Abstinence Family Family structure Families--Social aspects Families--Social conditions Family life Structure, Family Family relationships Relationships, Family Demography DemographicsCiter ce document
Swneke D. Bailey et al., « Common polymorphisms in the promoter of the visfatin gene (PBEF1) influence plasma insulin levels in a French Canadian population », CorpusUL, l'archive ouverte de l'université Laval, ID : 10.2337/db06-0189
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The adipokine visfatin (PBEF1) exhibits insulin-mimetic effects and correlates strongly with visceral adiposity. We sequenced visfatin gene exons and 1,480 bp of the promoter in 23 individuals, including 18 individuals from the Quebec Family Study (QFS) with varying degrees of abdominal visceral fat, assessed by computed tomography, and 5 individuals from the Saguenay-Lac-Saint-Jean region of Québec. We identified a synonymous polymorphism in exon 7 (SER301SER) but no nonsynonymous mutations. We observed an additional 10 polymorphisms, including 5 intronic, 4 within the promoter, and 1 within the 3' untranslated region. Further promoter sequencing (816 bp) identified five additional single nucleotide polymorphisms (SNPs) in the QFS population. To investigate the role of visfatin gene variants in obesity-related phenotypes, we genotyped a total of 13 SNPs in the promoter region of the gene. From these, we analyzed the seven common SNPs in the QFS sample (918 participants from 208 families). A significant association was found between two SNPs (rs9770242 and rs1319501), in perfect linkage disequilibrium, and fasting insulin levels (P = 0.002). These SNPs were also associated with fasting glucose (P
