Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

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Université Laval

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Ob protein

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Tuomas O. Kilpeläinen et al., « Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels », CorpusUL, l'archive ouverte de l'université Laval, ID : 10.1038/ncomms10494


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Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P

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