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- 20.500.11794/5768
- 1355-6037
- doi: 10.1136/heartjnl-2014-307154
- 25655063
http://purl.org/coar/access_right/c_16ec
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Aorte -- Rétrécissement HémodynamiqueSujets proches
Aortic stenosis Aortic valve stenosis Aortic valvular stenosisCiter ce document
Virginia Nguyen et al., « Haemodynamic and anatomic progression of aortic stenosis », CorpusUL, l'archive ouverte de l'université Laval, ID : 10.1136/heartjnl-2014-307154
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Background : Aortic valve stenosis (AS) is a progressive disease, but the impact of baseline AS haemodynamic or anatomic severity on AS progression remains unclear. Methods : In 149 patients (104 mild AS, 36 moderate AS and 9 severe AS) enrolled in 2 ongoing prospective cohorts (COFRASA/GENERAC), we evaluated AS haemodynamic severity at baseline and yearly, thereafter, using echocardiography (mean pressure gradient (MPG)) and AS anatomic severity using CT (degree of aortic valve calcification (AVC)). Results : After a mean follow-up of 2.9±1.0 years, mean MGP increased from 22±11 to 30±16 mm Hg (+3±3 mm Hg/year), and mean AVC from 1108±891 to 1640±1251 AU (arbitrary units) (+188±176 AU/year). Progression of AS was strongly related to baseline haemodynamic severity (+2±3 mm Hg/year in mild AS, +4±3 mm Hg/year in moderate AS and +5±5 mm Hg/year in severe AS (p=0.01)), and baseline haemodynamic severity was an independent predictor of haemodynamic progression (p=0.0003). Annualised haemodynamic and anatomic progression rates were significantly correlated (r=0.55, p
