Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia.

Fiche du document

Auteurs
Date

3 octobre 2015

Type de document
Périmètre
Langue
Identifiants
Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1093/ijnp/pyv110

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/26433393

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1469-5111

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_8A4015631DF28

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Animals; Brain/diagnostic imaging; Brain/growth & development; Brain/pathology; Brain/physiopathology; Diffusion Tensor Imaging; Disease Models, Animal; Glutamate-Cysteine Ligase/deficiency; Glutamate-Cysteine Ligase/genetics; Glutathione/deficiency; Male; Mice, Knockout; Organ Size; Pyrroles; Schizophrenia; Tissue Culture Techniques; White Matter/diagnostic imaging; White Matter/growth & development; White Matter/pathology; White Matter/physiopathology

Sujets proches En

Mouse House mice Mus musculus House mouse

Citer ce document

A. Corcoba et al., « Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia. », Serveur académique Lausannois, ID : 10.1093/ijnp/pyv110

Métriques

Partage / Export

Résumé 0

Structural anomalies of white matter are found in various brain regions of patients with schizophrenia and bipolar and other psychiatric disorders, but the causes at the cellular and molecular levels remain unclear. Oxidative stress and redox dysregulation have been proposed to play a role in the pathophysiology of several psychiatric conditions, but their anatomical and functional consequences are poorly understood. The aim of this study was to investigate white matter throughout the brain in a preclinical model of redox dysregulation. In a mouse model with impaired glutathione synthesis (Gclm KO), a state-of-the-art multimodal magnetic resonance protocol at high field (14.1 T) was used to assess longitudinally the white matter structure, prefrontal neurochemical profile, and ventricular volume. Electrophysiological recordings in the abnormal white matter tracts identified by diffusion tensor imaging were performed to characterize the functional consequences of fractional anisotropy alterations. Structural alterations observed at peri-pubertal age and adulthood in Gclm KO mice were restricted to the anterior commissure and fornix-fimbria. Reduced fractional anisotropy in the anterior commissure (-7.5% ± 1.9, P

document thumbnail

Par les mêmes auteurs

Sur les mêmes sujets

Exporter en