2014
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1101/gr.167742.113
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/24916972
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1549-5469
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_20CA18A8E5735
info:eu-repo/semantics/openAccess , CC BY-NC 4.0 , https://creativecommons.org/licenses/by-nc/4.0/
G. Giannuzzi et al., « Novel H3K4me3 marks are enriched at human- and chimpanzee-specific cytogenetic structures. », Serveur académique Lausannois, ID : 10.1101/gr.167742.113
Human and chimpanzee genomes are 98.8% identical within comparable sequences. However, they differ structurally in nine pericentric inversions, one fusion that originated human chromosome 2, and content and localization of heterochromatin and lineage-specific segmental duplications. The possible functional consequences of these cytogenetic and structural differences are not fully understood and their possible involvement in speciation remains unclear. We show that subtelomeric regions-regions that have a species-specific organization, are more divergent in sequence, and are enriched in genes and recombination hotspots-are significantly enriched for species-specific histone modifications that decorate transcription start sites in different tissues in both human and chimpanzee. The human lineage-specific chromosome 2 fusion point and ancestral centromere locus as well as chromosome 1 and 18 pericentric inversion breakpoints showed enrichment of human-specific H3K4me3 peaks in the prefrontal cortex. Our results reveal an association between plastic regions and potential novel regulatory elements.