Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.

E. Zimmermann; L.H. Ängquist; S.S. Mirza; J.H. Zhao; D.I. Chasman; K. Fischer; Q. Qi; A.V. Smith; M. Thinggaard; M.N. Jarczok; M.A. Nalls; S. Trompet; N.J. Timpson; B. Schmidt; A.U. Jackson; L.P. Lyytikäinen; N. Verweij; M. Mueller-Nurasyid; M. Vikström; P. Marques-Vidal; A. Wong; K. Meidtner; R.P. Middelberg; R.J. Strawbridge; L. Christiansen; K.O. Kyvik; A. Hamsten; T. Jääskeläinen; A. Tjønneland; J.G. Eriksson; J.B. Whitfield; H. Boeing; R. Hardy; P. Vollenweider; K. Leander; A. Peters; P. van der Harst; M. Kumari; T. Lehtimäki; A. Meirhaeghe; J. Tuomilehto; K.H. Jöckel; Y. Ben-Shlomo; N. Sattar; S.E. Baumeister; G. Davey Smith; J.P. Casas; D.K. Houston; W. März; K. Christensen; V. Gudnason; F.B. Hu; A. Metspalu; P.M. Ridker; N.J. Wareham; R.J. Loos; H. Tiemeier; E. Sonestedt; T.I. Sørensen

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.

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Date

2015

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Anglais

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doi: 10.1111/obr.12263
issn: 1467-7881

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1111/obr.12263

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/25752329

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info:eu-repo/semantics/altIdentifier/eissn/1467-789X

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_34CF5280131C2

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Patients--Mortality Mortality, Law of

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E. Zimmermann et al., « Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. », Serveur académique Lausannois, ID : 10.1111/obr.12263

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Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n = 169,551; 0.32 kg m(-2) ; 95% CI 0.28-0.32, P

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Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.

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