Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.

C.J. Hoggart; G. Venturini; M. Mangino; F. Gomez; G. Ascari; J.H. Zhao; A. Teumer; T.W. Winkler; N. Ternikova; J. Luan; E. Mihailov; G.B. Ehret; W. Zhang; D. Lamparter; T. Esko; A. Macé; S. Rüeger; P.Y. Bochud; M. Barcella; Y. Dauvilliers; B. Benyamin; D.M. Evans; C. Hayward; M.F. Lopez; L. Franke; A. Russo; I.M. Heid; E. Salvi; S. Vendantam; D.E. Arking; E. Boerwinkle; J.C. Chambers; G. Fiorito; H. Grallert; S. Guarrera; G. Homuth; J.E. Huffman; D. Porteous; D. Moradpour; A. Iranzo; J. Hebebrand; J.P. Kemp; G.J. Lammers; V. Aubert; M.H. Heim; N.G. Martin; G.W. Montgomery; R. Peraita-Adrados; J. Santamaria; F. Negro; C.O. Schmidt; R.A. Scott; T.D. Spector; K. Strauch; H. Völzke; N.J. Wareham; W. Yuan; J.T. Bell; A. Chakravarti; J.S. Kooner; A. Peters; G. Matullo; H. Wallaschofski; J.B. Whitfield; F. Paccaud; P. Vollenweider; S. Bergmann; J.S. Beckmann; M. Tafti; N.D. Hastie; D. Cusi; M. Bochud; T.M. Frayling; A. Metspalu; M.R. Jarvelin; A. Scherag; G.D. Smith; I.B. Borecki; V. Rousson; J.N. Hirschhorn; C. Rivolta; R.J. Loos; Z. Kutalik

Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.

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Date

2014

Discipline

Anthropologie biologique

Type de document

Articles

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Publications

Langue

Anglais

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doi: 10.1371/journal.pgen.1004508
issn: 1553-7390

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Serveur académique Lausannois

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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1004508

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/25078964

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info:eu-repo/semantics/altIdentifier/eissn/1553-7404

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_B24DBE741EAD2

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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BMI (Body mass index)

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C.J. Hoggart et al., « Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index. », Serveur académique Lausannois, ID : 10.1371/journal.pgen.1004508

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The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of ∼4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P

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Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.

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