Fiche du document
2006
- doi: 10.1621/nrs.04010
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1621/nrs.04010
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/16741568
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/1550-7629[electronic]
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D4A7B68B53C51
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Instruction and study--Methods Mobility Internal migration Gene expression--Regulation Gene regulation Gene expression regulation Instruction and study--MethodsCiter ce document
L. Gelman et al., « Integrating nuclear receptor mobility in models of gene regulation. », Serveur académique Lausannois, ID : 10.1621/nrs.04010
Métriques
Partage / Export
Résumé
The mode of action of nuclear receptors in living cells is an actively investigated field but much remains hypothetical due to the lack, until recently, of methods allowing the assessment of molecular mechanisms in vivo. However, these last years, the development of fluorescence microscopy methods has allowed initiating the dissection of the molecular mechanisms underlying gene regulation by nuclear receptors directly in living cells or organisms. Following our analyses on peroxisome proliferator activated receptors (PPARs) in living cells, we discuss here the different models arising from the use of these tools, that attempt to link mobility, DNA binding or chromatin interaction, and transcriptional activity.