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- 20.500.11794/39730
- 0021-9150
- doi: 10.1016/j.atherosclerosis.2007.01.002
- 17266964
http://purl.org/coar/access_right/c_16ec
Mots-clés
PCTP Positional candidate Gene variants Small LDL CHD risk factors Lipoprotéines de basse densité Lécithine Cœur -- Maladies -- Facteurs de risque Variabilité génétiqueSujets proches
PhosphatidylcholineCiter ce document
Claude Bouchard et al., « Influences of the phosphatidylcholine transfer protein gene variants on the LDL peak particle size », CorpusUL, l'archive ouverte de l'université Laval, ID : 10.1016/j.atherosclerosis.2007.01.002
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Résumé
Background: The small, dense LDL phenotype is associated with an increased cardiovascular disease risk. A genome-wide scan performed on 236 nuclear families of the Quebec Family Study (QFS) revealed a quantitative trait locus (QTL) affecting LDL peak particle size (LDL-PPD) and density on the 17q21 region. This region contains the phosphatidylcholine transfer protein gene (PCTP). In the liver, phosphatidylcholine transfer protein binds specifically phosphatidylcholine suggesting a role for this protein in the formation of HDL and possibly VLDL phospholipid membranes. Objectives: To test the association between two coding polymorphisms (c.29A>C (Glu10Ala) and c.188G>A (Cys63Tyr)) in PCTP gene and the LDL-PPD. Methods: LDL-PPD was measured by non-denaturating 2–16% polyacrylamide gradient gel electrophoresis on 623 QFS subjects. Results: After adjustment for age and sex, carriers of the c.29C allele showed larger LDL-PPD than A/A homozygotes (p < 0.05). These results remained significant when LDL-PPD was further adjusted for the effects of BMI and triglyceride levels (p < 0.04). We also observed a three-fold lower risk of having the small (LDL-PPD
