The intestine is the largest digestive organ in the human body and one of the largest organs in contact with the outside world. In addition to digesting food to facilitate the absorption of nutrients, it has a variety of other functions, including the transmission of information and regulation of th...
Dermatitis herpetiformis (DH) is a pruritic papulovesicular disease that is relatively common in Caucasian populations, and was first reported by Louis Duhring. It is characterized by granular IgA deposition in the dermal-epidermal junction and gluten-sensitive enteropathy (GSE) associated with huma...
Among gluten-related disorders, coeliac disease (CD) is the best-known one to date, a chronic immune-mediated enteropathy triggered by exposure to gluten in genetically predisposed individuals. It is a common disease, occurring at all ages and characterized by a wide spectrum of clinical manifestati...
The extraintestinal manifestations of coeliac disease (CD) are now well recognised. We have previously edited a special issue for Nutrients covering all aspects of the extraintestinal manifestations in the context of CD. In this issue we wish to concentrate just on the neurological manifestations. T...
Chronic intestinal diseases are increasing around the world. With poor quality of life and expensive healthcare costs, the patients demand novel approaches and treatments for better clinical outcomes. This book illustrates the state of the art and the envisaged near future in the management of these...
Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein-Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointesti...
Several studies confirmed a correlation between elevated hydrogen peroxide (H2O2) levels in patients with intestinal bowel diseases (IBD) and the negative effects caused by its presence. The objective of this study was to explore the potential use of catalase (CAT) to diminish the level of H2O2 and...
Comparisons of mammalian gut microbiota across different environmental conditions shed light on the diversity and composition of gut bacteriome and suggest consequences for human and animal health. Gut bacteriome comparisons across different environments diverge in their results, showing no generali...
The central goal of this study was to analyze scientific trends in the research on probiotics, including the number of papers, funding, country collaborations, and most cited publications. The study makes use of bibliometric and social network analysis of papers included in the Science Citation Inde...
Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145 patients (median age-at-diagnosis of 3.5 years), in whom no Mendelian disorders were cl...
Epizootic rabbit enteropathy (ERE) represents one of the most devastating diseases affecting rabbit farms. Previous studies showing transmissibility of disease symptoms through oral inoculation of intestinal contents from sick animals suggested a bacterial infectious origin for ERE. However, no etio...
Η εμφάνιση εντερίτιδων στα κουνέλια είναι ιδιαίτερα συχνή. Μέχρι σχετικά πρόσφατα, η αιτιολογία τους δεν ήταν επαρκώς διευκρινισμένη και με όρους, όπως «μη ειδική εντερίτιδα», περιγράφονταν παθολογικές καταστάσεις που αφορούσαν σε μέρος ή και σε ολόκληρο το πεπτικό σύστημα των κουνελιών. Τα τελευταί...
Η Επιζωοτική Εντεροπάθεια του Κονίκλου (ΕΕΚ) είναι ένα από τα σημαντικότερα σύνδρομα που εμφανίστηκαν την τελευταία δεκαετία στις εκτροφές κονίκλων των ευρωπαϊκών χωρών και προκαλεί πολυάριθμους θανάτους κυρίως στο στάδιο της πάχυνσης. Διαπιστώθηκε αρχικά στη Γαλλία, το 1997, αλλά πολύ γρήγορα εξαπλ...
Τα κουνέλια πάσχουν από την Επιζωοτική Εντεροπάθεια των Κουνελιών (ΕΕΚ) (Epizootic Rabbit Enteropathy,ERE), η οποία αποτελεί σύνδρομο του γαστρεντερικού σωλήνα αγνώστου αιτιολογίας. Η ΕΕΚ δεν έχει ακόμη πλήρως μελετηθεί όσο αναφορά τη παθοφυσιολογια της δυσλειτουργίας του εντέρου, κατά τη διάρκεια τ...
Immune dysregulation, Polyendocrinopathy, Enteropathy X-linked (IPEX) syndrome is a unique example of primary immunodeficiency characterized by autoimmune manifestations due to defective regulatory T (Treg) cells, in the presence of FOXP3 mutations. However, autoimmune symptoms phenotypically resemb...
Dysregulation of intestinal epithelial cell performance is associated with an array of pathologies whose onset mechanisms are incompletely understood. While whole-genomics approaches have been valuable for studying the molecular basis of several intestinal diseases, a thorough analysis of gene expre...